Pharmacopeia Announces Upcoming Late-Breaker Presentation Of Phase 2a Results For Its First-in-Class Investigational DARA Compound, PS433540
Pharmacopeia
(Nasdaq: PCOP), an innovator in the discovery and development of novel
small molecule therapeutics, announced that results from the
company’s Phase 2a clinical trial evaluating PS433540, its first-in-class
Dual Acting Receptor Antagonist (DARA), will be presented as a
late-breaking clinical trial at the American Society of Hypertension (ASH)
Twenty-Third Annual Scientific Meeting and Exposition in New Orleans, May
14-17, 2008.
PS433540 is being developed as a potential treatment for both
hypertension and diabetic nephropathy and is the first and only blood
pressure product candidate in development that possesses two validated
mechanisms of action in a single compound.
Joel Neutel, MD, lead investigator and Director of Research, Orange
County Research Center, Tustin, Calif., will present results of the Phase
2a clinical trial. In addition to the late-breaker, Pharmacopeia will also
present data from its Phase 1 Multiple Ascending Dose (MAD) Study of
PS433540.
Late-breaker presentation:
– "A Double Blind, Placebo Controlled Study to Evaluate the Safety and
Efficacy of a Novel New Dual Acting Receptor Antagonist (DARA
Compound) in Human Subjects with Hypertension"
– Friday, May 16, 2008, 5:38 - 5:55 p.m. CDT (6:38 - 6:55 p.m. EDT)
– New Orleans Marriott, Acadia Ballroom, 3rd Floor
Poster presentation:
– "PS433540 a Novel Dual Acting Receptor Antagonist Dose Dependently
Increases Plasma Renin Activity in Healthy Volunteers"
– Abstract # P-14
– Wednesday, May 14, 2008, Posters on Display: 3:00 - 7:00 p.m. CDT
(4:00 - 8:00 p.m. EDT), Poster Discussion: 5:15 - 6:15 p.m. CDT
(6:15 - 7:15 p.m. EDT)
– New Orleans Marriott, Le Galerie Ballroom, 2nd Floor
About Pharmacopeia
Pharmacopeia is a clinical development stage biopharmaceutical company
dedicated to discovering and developing novel small molecule therapeutics
to address significant medical needs. The company has a broad portfolio of
clinical and preclinical candidates under development internally or by
partners including eight clinical compounds in Phase 2 or Phase 1
development addressing multiple indications including hypertension,
diabetic nephropathy, muscle wasting, inflammation and respiratory disease.
The company is leveraging its fully integrated drug discovery platform to
sustain the growth of its development pipeline. Pharmacopeia has
established strategic alliances with major pharmaceutical and biotechnology
companies, including Bristol-Myers Squibb, Celgene, Cephalon,
GlaxoSmithKline, Schering-Plough, and Wyeth Pharmaceuticals. For more
information please visit the company’s website at
This press release, and oral statements made with respect to
information contained in this press release, constitute forward-looking
statements within the meaning of the Private Securities Litigation Reform
Buy lasix without prescription Act of 1995. Such forward-looking statements include those which express
plan, anticipation, intent, goal, contingency or future development and/or
otherwise are not statements of historical fact. These statements are based
upon management’s current expectations and are subject to risks and
uncertainties, known and unknown, which could cause actual results and
developments to differ materially from those expressed or implied in such
statements. These forward-looking statements include, but are not limited
to, statements about the successful implementation of Pharmacopeia’s
strategic plans, Pharmacopeia’s plans to develop PS433540, a product
candidate from its DARA program, Pharmacopeia’s Phase 2 and Phase 1
clinical studies with respect to PS433540, including timing and expected
outcomes of such studies, Pharmacopeia’s plans to develop PS178990, a
product candidate from its SARM program, Pharmacopeia’s Phase 1 clinical
studies with respect to PS178990, including timing and expected outcomes of
such studies, Pharmacopeia’s plans to develop PS031291, a product candidate
from its chemokine receptor CCR1 program, Pharmacopeia’s estimates of the
market opportunities for its product candidates, including PS433540,
PS178990 and PS031291, Pharmacopeia’s ability to raise additional capital,
Pharmacopeia’s anticipated operating results, financial condition,
liquidity and capital resources, Pharmacopeia’s ability to successfully
perform under its collaborations with Bristol-Myers Squibb, Cephalon,
GlaxoSmithKline, Schering-Plough and Wyeth, Pharmacopeia’s ability to build
its pipeline of novel drug candidates through its own internally-funded
drug discovery programs, third party collaborations and in-licensing,
Pharmacopeia’s expectations concerning the development priorities of its
collaborators, their ability to successfully develop compounds and its
receipt of milestones and royalties from the collaborations, Pharmacopeia’s
expectations concerning the legal protections afforded by U.S. and
international patent law, Pharmacopeia’s ability to pursue the development
of new compounds and other business matters without infringing the patent
rights of others, additional competition, and changes in economic
conditions.
Further information about these and other relevant risks and
uncertainties may be found in Pharmacopeia’s Reports on Form 8-K, 10-Q and
10-K filed with the U.S. Securities and Exchange Commission. Pharmacopeia
urges you to carefully review and consider the disclosures found in its
filings which are available in the SEC EDGAR database at
and from Pharmacopeia at All forward-looking
statements in this press release and oral statements made with respect to
information contained in this press release are qualified entirely by the
cautionary statements included in this press release and such filings.
These risks and uncertainties could cause actual results to differ
materially from results expressed or implied by such forward-looking
statements. These forward-looking statements speak only as of the date of
this press release. Pharmacopeia undertakes no obligation to (and expressly
disclaims any such obligation to) publicly update or revise the statements
made herein or the risk factors that may relate thereto whether as a result
of new information, future events, or otherwise.
Pharmacopeia
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